COVID Proteins, Substrates and Probes
All substrates were designed using HyCoSuL technology (Hybrid Combinatorial Substrate Library, Poreba et al., Nature Protocols, 2017, (10): 2189-2214) in which natural and unnatural amino acids are used to optimize protease specificity of the tetrapeptide substrates. All substrates are linked to an ACC fluorophore due to its 2.8 -fold higher fluorescence quantum yield at the excitation and emission wavelengths of 380 nm and 460 nm. This results in higher sensitivity of the assay.
Showing all 6 results
-
SARS-CoV-2-Mpro Substrate
Ac-Thz-Tle-Leu-Gln-ACC is a peptide substrate for both SARS-CoV-2 and SARS-CoV main protease, Mpro (also known as 3CLpro). Molecular weight: 729.32, KM = 189.5 ± 2.7 µM, kcat = 0.144 ± 0.006 s-1, Kcat/KM = 760 ± 50 M-1s-1 Ref. Rut et al. https://bit.ly/3EIP2r0Price range: £850.00 through £3,300.00Species: N/A
Source: N/A
Expression: N/A
Cell Line: N/A
Sequence Type: N/A
SKUs: 10500, 10501
-
SARS-CoV-2-Mpro Substrate
Ac-Abu-Tle-Leu-Gln-ACC is a peptide substrate for both SARS-CoV-2 and SARS-CoV main protease, Mpro (also known as 3CLpro). Molecular weight: 699.36, KM = 207.3 ± 12 µM, kcat = 0.178 ± 0.016 s-1, kcat/KM = 859 ± 57 M-1s-1. Ref. Rut et al. https://bit.ly/3lPVK70Price range: £850.00 through £3,300.00Species: N/A
Source: N/A
Expression: N/A
Cell Line: N/A
Sequence Type: N/A
SKUs: 10503, 10502
-
SARS-CoV-2-Mpro Substrate
Ac-Val-Lys-Leu-Gln-ACC is a peptide substrate for both SARS-CoV-2 and SARS-CoV main protease, Mpro (also known as 3CLpro). Molecular weight: 728.39, KM = 228.4 ± 9.9 μM, kcat = 0.050 ± 0.002 s-1, kcat/KM = 219 ± 3 M-1 s-1 Ref. Rut et al. https://bit.ly/3lPVK70Price range: £850.00 through £3,300.00Species: N/A
Source: N/A
Expression: N/A
Cell Line: N/A
Sequence Type: N/A
SKUs: 10504, 10505
-
SARS-CoV-2-PLpro Substrate
Ac-Leu-Arg-Gly-Gly-ACC is a peptide substrate for both SARS-CoV-2 and SARS-CoV Papain-Like cysteine protease, PLpro. Molecular weight: 643.31, kcat/KM = 912 ± 49 M-1 s-1 Ref. Rut et al. https://bit.ly/3dCAHAuPrice range: £850.00 through £3,300.00Species: N/A
Source: N/A
Expression: N/A
Cell Line: N/A
Sequence Type: N/A
SKUs: 10506, 10507
-
SARS COV-2 Mpro protease
Price range: £360.00 through £3,000.00Species: SARS COV-2
Source: Bacterial
Expression: Recombinant
Cell Line: E. coli
Sequence Type: Wild-Type
SKUs: 10508, 10509
-
SARS COV-2 PLpro protease
Price range: £360.00 through £3,000.00Species: SARS COV-2
Source: Recombinant
Expression: Bacterial
Cell Line: E. coli
Sequence Type: Wild-Type
SKUs: 10511, 10510